유기 화학에서 새로운 물질이 지속적으로 발견되고 있지만,
연구원들은 그들의 연구과제에 가장 적합한 물질을 필요로 하며 계속 찾고 있습니다.
Building Blocks은 유기 합성의 기본으로 분자 구조의 상향식 모듈 조립에 사용됩니다.
연구원들의 신약 후보 물질 발굴 및 차세대 물질 연구 개발을 위해
㈜씨케이테크놀러지에서는 최적의 제조사를 Sourcing하여 시약을 납품 드리겠습니다.
Building Blocks Scheme
Amino acids are the building blocks of peptides and proteins.
All amino acids contain an amine group, a carboxylic acid group,
and a side-chain that varies for each amino acid.
The side chains differ in polarity and pKa and are important to
both protein structure and function.
Pyridine is the basic heterocyclic compound of the azine kind.
Pyridine is derived from benzene through replacement of the CH group
by the N-atom. Pyridine and picolines are employed as bases,
scavengers, catalysts, as well as solvents for chemical reactions.
Chiral molecules show left and right-handed nature in the sense
that the molecules may exist as mirror-image forms
that cannot be made to overlap by any amount of rotation.
Boronic acid is a stable and generally a non-toxic group
that is easily synthesized and, due to these features, can be used
in several synthetic reactions including metal-catalyzed processes
such as Suzuki–Miyaura reaction, acid catalysis, asymmetric synthesis
of amino acids, and hydroboration.
Heterocyclic compounds are frequently used in organic synthesis.
Many of the heterocyclic scaffolds have been identified
as a privileged structure in medicinal chemistry and are prevalent
in a variety of pharmacologically active synthetic and natural compounds.
Most chemical reaction design planning starts
from these commercially available heterocyclic building blocks.
Stable isotopically labeled compounds are non-radioactive
chemical substances where one or more element
within a compound has been substituted for its stable isotope.
Common stable isotopes used in research
include 2H (Deuterium or D), 13C, 15N and 18O.
Fluorine is the most electronegative of all the elements, and forms very strong bonds to carbon and most other elements.
Its small atomic radius enables replacement of one or more hydrogen atoms in an organic structure by fluorine with relatively little steric impact, but often with a profound influence on the stability, biological availability and activity of the resulting molecule.
Elemental fluorine is one of the most chemically reactive substances known, which, along with the high toxicity of both fluorine and hydrogen fluoride, and their incompatibility with common materials, including glass, necessitate highly specialized equipment and techniques for reactions in which they are involved.
Direct fluorination of a pre-existing organic structure with either F2 or HF may thus appear daunting to the non-specialist.
Polyethylene glycol is a biologically inert, non-immunogenic
chemical that confers greater water solubility to proteins,
labeling tags and crosslinkers with which it is incorporated
as constituent chemical group.
PEG linkers are widely used in pharmaceutical
and biotech R&D due to their aqueous solubility and non-immunogenicity.
- Amino Acids
- Chiral Compounds
- Boronic Acids
- Heterocyclic Compounds
- Labeled Compounds
- Fluorinated Compounds
- PEG Linkers
스크리닝(Screening)은 신약 개발 중 신약 후보물질이 될 수 있는 합성 화합물 등의
약리 활성 및 독성을 평가하는 과정으로 대표적으로 HTS 방법이 있습니다.
다년간의 경험을 바탕으로 타깃 물질 또는 물성 정보 (CAS, SMILES, INCHI-Key)를 이용하여
필요한 용량만큼 가장 빠르게 재고 보유 업체를 선별하여 Sourcing 및 납품 드릴 수 있습니다.
HTS (High Throughput Screening)